Every October, we publish our Hot 20, a series of profiles on the city's most up-and-coming movers and shakers. Former Hot 20s have included local luminaries such as Instagram founders Mike Krieger and Kevin Systrom, District 6 Supervisor Jane Kim, SF Giants pitcher Tim Lincecum, and Off the Grid owner and operator Matt Cohen. We're gearing up to select our 2012 class and are now accepting submissions for the Readers' Choice spot.

Send us your submissions! Your nominee must be a Bay Area resident who is shaking things up and poised to do great things in the coming years. We're looking for nominations across all areas and disciplines: arts, science, tech, food, politics, design, sports, environmentalism, literature... you name it.

Send in your nomination, along with a short paragraph explaining your choice to hot20@7x7.com with the subject line HOT20.

We'll be accepting nominations until Monday, July 30 at midnight. Reader voting will begin on August 3 with our top 25 picks. A second round of voting on the top seven will begin on August 10 and continue until 5 p.m on Friday, August 17.

The winner of the popular vote will appear in 7x7's October 2012 issue!